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Scientists (10)

Name Rating Voted startups Country Works Vote
1 589 58 UK 2 VOTE
2 589 58 UK 10 VOTE
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Works (20)

Name Work Domain Description work Source
When stem cells grow old: phenotypes and mechanisms of stem cell aging. Sinclair D.A. Cell biology

Recent advances in our understanding of why adult stem cells age and how this aging impacts diseases and lifespan. With this increased understanding, it is feasible to design and test interventions that delay stem cell aging and improve both health and lifespan

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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. Sinclair D.A. Genomics

Overexpression of SIRT2 or treatment of mice with the NAD(+) precursor nicotinamide mononucleotide (NMN) increases BubR1 abundance in vivo. Overexpression of SIRT2 in BubR1(H/H) animals increases median lifespan, with a greater effect in male mice. Together, these data indicate that further exploration of the potential of SIRT2 and NAD(+) to delay diseases of aging in mammals is warranted.

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History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents. William C. Campbell Pharmacology

History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents. Campbell’s group showed that Avermectin B1 had potency and safety superior to all known antihelminthic therapies at the time, capable of resolving a wide variety of animal nematode (roundworm) infections. The special applications in human medicine were developed, and were successfully implemented in partnership with World Health Organization.

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The Sequence of the Human Genome. J. Craig Venter Genomics

Our first human genome sequence article, featured here, represented a significant scientific milestone not just because it was the first human genome sequence. The method used to sequence the genome—the whole-genome shotgun (WGS) strategy—was at the time considered radical

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