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Traditional coloring book become more associated with mindfulness, stress and anxiety management. According to Time roughly 24 million adult coloring books were sold during 2017-2018 years. The digitalization of coloring books gives a new opportunity and could be using for improving of current mental state. The coloring apps developed and now available for smartphone and tablet users with millions of downloads. Those apps have traditional entertainment goal and include more and more additional opportunities for users.

Digital approach became useful during classes and therapy of children with autism spectrum disorders. Tutor Yevgeny (psychologist, teacher) shares his experiences of using mobile applications with during his work.

Life Biosciences announced Academies for Health and Lifespan researches. The Academy for Health and Lifespan Research was recently announced, an initiative analogous to that of the long-running Longevity Dividend group, but hopefully more energetic and more focused on at least some rejuvenation biotechnologies such as senolytic therapies. The principals include many of the researchers now involved in startup biotech companies working on ways to intervene in the mechanisms of aging, and the goal is to generate greater support for development of means to slow or reverse aging and age-related disease. David Sinclair is associated with Life Biosciences and its collection of portfolio companies, and here discusses the Academy and its future role.

Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells. Recent evidence has shown that transient transgenic reprogramming can ameliorate age-associated hallmarks and extend lifespan in progeroid mice

Dr. David Sinclair reports that the NAD boosting NMN compound reverses aging in blood vessels and restores muscle strength in a new study published March 22nd. Vascular aging causes many diseases — cardiovascular, neurological, muscle wasting, frailty, and even aging. Sinclair Lab at Harvard Medical School has reversed the process in mice, setting the stage for radical new therapies to help people. The new study has unraveled the cascade of interactions between blood vessels and muscles. The two key players in the crosstalk between blood vessels and muscles are a molecule called NAD and a protein called SIRT1. NAD boosts SIRT 1, which in turn enables the conversation between muscles and blood vessels. But both NAD and SIRT1 decline as we age. They can no longer perform their role as the interface between muscles and blood vessels. Sinclair gave mice NMN, a chemical compound commonly found in the body and previously shown to boost NAD levels, which in turn boosts SIRT1. These mice had better endothelial function, blood vessel growth and improved blood supply to their muscles. Sinclair believes that the results achieved in mice can eventually be translated to humans, helping to counter age-related diseases with a vascular component, such as frailty, heart attack, stroke or even forms of dementia such as Alzheimer’s disease.